Two hundred ninety-four children from low-income families (58% White, 17% Latinx, 25% Black; 54% girls; M[subscript age] = 4.49 years old at study entry) were recruited from Head Start classrooms to participate in a randomized-controlled trial of the project REDI (Research-based, Developmentally Informed) preschool intervention and then followed longitudinally for 10 years through ninth grade. At study entry, parents reported on their children's exposure to adverse experiences (ACEs). Youth reported on their feelings of social-emotional distress and school bonding after making the transition into middle school (seventh grade) and high school (ninth grade). Multilevel latent profile analyses revealed three profiles of adolescent distress and school bonding. Increased rates of ACEs in early childhood predicted membership in adolescent profiles characterized by heightened social-emotional distress and reduced levels of school bonding. The REDI intervention that focused on promoting early social-emotional and language skills in preschool moderated the impact of early ACEs on adolescent adjustment and promoted youth resilience, significantly buffering children from the negative impact of early ACEs on their levels of social-emotional distress and school bonding. [This paper was published in "School Psychology" v35 p285-298 2020.]