Early care and education (ECE) leaders often consider new content, curricula, and models to include in their quality improvement (QI) toolkit. The Breakthrough Series Collaborative (BSC) centers equity in its approach to engaging staff at all levels in an ECE program. It is a promising approach for center-based ECE programs (with the potential to be used with home-based programs). While states are in a unique position of urgently managing pandemic relief funds and addressing high-priority needs for stabilization of child care programs in particular, they are also being challenged to address the needs of families and children (including families with low incomes) who have not had equitable access to ECE programs that provide high-quality care, even prior to the pandemic. Leaders are looking for innovations that can address the challenges in the current system. The purpose of this brief is to provide federal, state, and local ECE leaders with an overview of a quality improvement methodology called the Breakthrough Series Collaborative (BSC) and to describe the potential to use the BSC in early childhood systems to help ECE programs build their capacity for continuous improvement and make sustained changes in evidence-based practices. This brief focuses on quality improvement in center-based ECE contexts, though many of the general points made throughout are also applicable to quality improvement with home-based providers. [This report was prepared with JRA Consulting, Ltd.]