Our most vulnerable students experience multiple and repetitive exposure to overlapping negative experiences that impact them emotionally, psychologically, and physically as a result of their intersecting identities and factors. Race and/or socio-economic class are highlighted as the most significant indicators for the achievement of Blacks and Latinos. Add the negative effect of trauma, and these students face nearly insurmountable odds in their struggle to escape marginalization. In this article, I argue that Social Justice Leadership is the most effective strategy to help marginalized students create opportunities to move beyond the intersection of these identities and factors and increase their chance to prosper while maintaining their humanity. A Social Justice Framework that includes the foundational concepts of Cultural Responsiveness, Diversity & Inclusion, Educational Justice and Trauma-informed Care is the most effective strategy to combat and dismantle institutional racism and advance social justice. This approach increases the probability that the negative effects of the intersectionality of racism, classism, and trauma can be diminished.