The article presents the benefits of successful collaboration between supported employment agencies and human resource managers when working together to secure employment for individuals with disabilities. Two case studies are presented: one involving a successful collaboration with county human resource managers in negotiating a change in the hiring process and the other discussing the results of a negotiated agreement between the state level WorkAbility Program office and a company's national human resource office. Both cases resulted in the hiring of individuals with disabilities. Also included is a perspective, from a director of human resource services in the private sector, which examines specific Americans With Disabilities Act issues that present barriers to hiring individuals with disability. Suggested strategies supported employment agencies can use for effective collaboration with human resource management are identified. (Contains 1 table.)