Sepsis kills more than 250,000 people every year in the United States. Immediate treatment is crucial for best patient outcomes but sepsis can be challenging to identify. Nurses may miss signs of sepsis and delay life-saving treatment. The purpose of this quality improvement project was to determine whether an instructional presentation on introduction to sepsis followed by a high fidelity sepsis simulation scenario would improve knowledge and confidence in early recognition of and response to signs of sepsis for final semester associate degree nursing (ADN) students. Tanner's Clinical Judgment Model was used as the theoretical framework for this project. The project administrator used a convenience sample of 32 ADN students at a southeastern United States community college and pre tested them for knowledge and confidence with a sepsis knowledge quiz and C-Scale©. After a sepsis education presentation and high fidelity sepsis simulation scenario and debriefing, 31 students completed post testing with the same two instruments. Independent samples t-tests were used to compare changes in pre and posttest group mean scores. Results from both the sepsis knowledge quiz and the confidence scale showed a significant increase (p < 0.001) for group mean scores. These results affirm that there is a positive effect on knowledge and confidence in ADN students who have sepsis education followed by a sepsis simulation scenario and debriefing. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]