The current study examines hope and career adaptability as two potential mediators, parent-child closeness as a moderator of the relationship between career-related parental support and life satisfaction. A total of 521 vocational high school students responded to this study. The result revealed that hope and career adaptability independently and serially mediated the relationship between parental career-related support and life satisfaction. Moreover, the moderating effect of parent-child closeness on career-related parental support and hope was found. When students' parent-child closeness was high (vs. low), the indirect pathway linking parental career-related support to hope to career adaptability to life satisfaction was stronger. This study enlightens parents should give career-related support to their children and establish a close bond with children.