Abstract An interactive multimedia software program was developed for teaching punctuation strategies and then tested with middle-school and high-school students with learning disabilities. Students at each school level were randomly selected into an experimental or control group. Results showed that experimental students at both school levels performed similarly by earning significantly higher scores on a test of punctuation usage than the control students. Additionally, experimental students in both school cohorts inserted significantly fewer incorrect punctuation marks than the controls. Furthermore, the experimental students generalized their use of the strategies to a test where they wrote their own sentences. Thus, this study shows that students with LD can learn punctuation strategies at a high level of mastery and can generalize their skills to sentence editing and sentence construction tasks when taught through interactive multimedia.