This study addressed teachers' perceptions of barriers faced by inner-city African American high school female students in STEM courses. This qualitative descriptive study examined STEM teachers' perceptions of barriers inner-city African American female students encounter when enrolled in STEM courses. The research questions addressed STEM teachers' perceptions of the barriers that impede inner-city African American high school female students from enrolling in STEM courses, strategies to overcome barriers to students' success, and strategies to recruit for STEM courses. Eleven STEM teachers responded to 14 open-ended interview questions. Their responses were recorded and transcribed in NVivo, which produced codes for common themes. Participants' perceptions of barriers were inadequate preparation and readiness to take STEM courses, student background, lack of confidence, fear of failure, and inadequate educational relationships. Participants' perceptions of strategies to help students overcome barriers included supporting students by providing adequate resources, motivating, and encouraging students, helping students establish foundational relationships, and increasing their exposure to STEM courses. Participants' perceptions of strategies to recruit students to STEM courses were to provide an increased awareness of STEM courses, provide support and resources, and help students become more aware of future opportunities. One conclusion was that implementing culturally responsive teaching practices, providing hands-on activities, and implementing collaborative inquiry-based learning methods can create supportive and inclusive learning environments. It was also concluded that providing STEM learning experiences at an earlier age is integral to students enrolling in STEM courses. Further research is recommended to gain a deeper understanding of these barriers as well as evidence-based interventions that empower and support the pursuit of STEM education. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]