This qualitative single case study provides insights on the influences of assistive technology on students with vision impairments within the middle and high school grade levels. The problem addressed in this study is students with vision impairment face limitations in accessing the educational curriculum; however, when assistive technology recommendations are made, student input is not considered. The purpose of this study is to address the problem of students with vision impairment accessing appropriate tools by highlighting the academic influences of assistive technology through the perception of students with visual impairments. Research Question 1 includes how assistive technology supports learning outcomes for students with vision impairment. Research Question 2 What are the perceptions of students with vision impairments on the usage of assistive technology? The theoretical structure of this study is based on Shulman's Technological Pedagogical Andragogy Content Knowledge (TPACK). The TPACK framework recommends the role of technology in learning to make positive contributions, such as accessibility to the curriculum. This study was designed by collecting in-depth detailed qualitative evidence through two qualitative instruments, an open-ended survey, and a semi-structured interview. The sample for this study is from a middle and high school district located in San Diego, California, where 13 qualifying students were eligible for participation. These eligible students receive an individualized education plan under the qualifying condition of vision impairment. Eight students completed both qualitative activities. The findings include three themes and one sub-theme were the most considerable influence of the assistive technology support on students with vision impairments; enlarge, accessibility, magnification, and sub-theme zoom. Future research should focus on the influences of assistive technology on other varieties of learning disabilities. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]