With an emergence of research investigating the educational impacts of the COVID-19 pandemic, empirical studies assessing teachers' mental health throughout the pandemic have been scarce. Using a large national data set, the current study compares mental health outcomes during the pandemic between pre-K-12 teachers and professionals in other occupations. Further, we compare the prevalence of mental health outcomes between in-person and remote teachers (N = 134,693). Findings indicate that teachers reported a greater prevalence of anxiety symptoms than did those in other professions and that remote teachers reported significantly higher levels of distress than did those teaching in person. We summarize the policy implications of these results.