To combat educational and health disparities, out-of-school-time (OST) STEM enrichment programs provide services to underserved youth to encourage them to pursue college and health careers. This article describes a study conducted to determine if the Health Sciences and Technology Academy (HSTA) program participants who receive year-round educational interventions to prepare them for STEM and health sciences majors performed better on the West Virginia Educational Standards Test (WESTEST2) than non-participants. This study provides descriptive and inferential statistics, specifically one-way ANOVAs with one-to-one matching based on grade level, gender, race, and GPA at the end of the 8th grade year for 336 students. Statistically significant differences were found favoring HSTA participants on the WESTEST2 math and reading/language scores.