This study explores the sense of belonging of rural middle and high school Latinx science students in Wisconsin. Between 2000 and 2015, the Latinx population was the fastest growing ethnic group in Wisconsin and increased by 95%. Yet, little is known about the experiences of these students in rural schools or their engagement in science learning. Our research contributes to addressing this knowledge gap and provides insights into Latinx student experiences relative to the science classroom and community. Our findings indicate that a primary determinant of Latinx science students' positive sense of belonging is a positive relationship with their teachers.