Most studies of academic inbreeding have focused on assessing its impact on scholarly practices, outputs, and outcomes. Few studies have concentrated on the other possible effects of academic inbreeding. This paper draws on a large number of studies on academic inbreeding to explore how the practice has been conceptualized, how it has emerged, and how it has been rationalized in the creation and development of higher education systems. Within this framework, the paper also explores how academic inbreeding shapes and maintains a powerful academic oligarchy, leading to the stonewalling of both knowledge and institutional change to maintain social and political structures somewhat akin to those of medieval societies. The paper shows that the key to mitigating academic inbreeding practices lies in ensuring that academic recruitment processes are open, meritocratic, and transparent. However, a more difficult task is to change longstanding mentalities and disrupt a system that serves the interests of certain groups but not the advancement of knowledge or the fulfillment of universities' social mandates.