This study explored the impact of a meditation program on stress, anxiety, and depression in a high-performing high school. Using a randomized controlled design with 52 students, the study took place over 4 months. Students participated in Transcendental Meditation (treatment) or silent reading (active control) twice daily. We observed significant reductions in perceived stress (p = 0.040), anxiety (p = 0.028), anger (p = 0.047), depression (p = 0.024), and fatigue (p = 0.075), and improvement in self-esteem (p = 0.054). The program has important implications for school counselors because of the impact on social/emotional well-being.