The study aimed to determine which of the domains in school quality significantly influence the self-esteem of CNHS learners. The quantitative non-experimental design using the correlational technique was used in the study. It was conducted in Compostela National High School involving 300 Junior High learners, specifically learners of grade 7, grade 8, grade 9, and grade 10 for the School Year 2018-2019. Moreover, the statistical tools used in the study were Mean, Pearson Product Moment of Correlation, and Regression. The study revealed a high level of school quality and self-esteem in the learners. The study also found a significant relationship between school quality and self-esteem. Further, the study revealed that the combined domains of school quality significantly influence the self-esteem of Compostela National High School learners. In the institution mentioned above, among the domains of school quality, professionalism and capacity of the system and responsiveness of the system has the greatest influence on the self-esteem of the learners.