We learn by doing. This simple philosophy is at the heart of project-based learning in the 21st-century classroom. It is grounded in the belief that the stand and lecture approach to teaching, worksheets and rote memorization are not enough to move students down a path to the deep learning necessary for success in college and careers. Essential are interdisciplinary teaming and career academies focusing heavily on involving students in authentic, real-world assignments requiring a mix of hands-on activities, critical thinking, technology and soft skills. This issue of the Best Practices Newsletter describes best practices in implementing the High Schools that Work (HSTW), Making Middle Grades Work (MMGW), and Technology Centers That Work (TCTW) school improvement models based on presentations at the 28th Annual HSTW Staff Development Conference in Nashville, Tennessee in the summer of 2014. The following pieces are included: (1) Diving Into Project-Based Learning; (2) Interdisciplinary Teaming and Project-Based Learning; (3) Interdisciplinary Teams Addressing the Needs Students; (4) Engaging Career and Technical Education Students in Reading and Writing; and (5) Career and Technical Education Students Stand Out Thanks to Career Portfolios.