The Multi-Tiered System of Support (MTSS) framework, which uses a systems approach to promote school improvement and support all students in improving academics and behavior using data-based problem-solving, is a key part of the Wake County Public Schools System (WCPSS) Strategic Plan. As of 2017-18, MTSS schools were at the initial stages of MTSS implementation and showed no significant improvement in Grades 3 and 8 reading proficiency, overall achievement, or Education Value-Added Assessment System (EVAAS) growth ratings that could be attributed to MTSS implementation. Suspension rates and eligibility for special education in high incidence categories were not yet a focus for the practices or professional learning and were also not positively affected by MTSS. However, a higher percentage of teachers in treatment than control elementary schools reported that MTSS positively affected student achievement in their schools. Additionally, MTSS had a positive effect on Hispanic/Latino students' 2017-18 graduation rates and on reduction of their special education eligibility rates at elementary schools. The initial results suggest that MTSS should remain a district priority with an ongoing leadership support, expanded focus on tiered supports and on the behavioral component of MTSS.