In response to indicators that a decline in interest in mathematics occurs among girls--particularly those from low-income and minority groups--during middle school, the GO-GIRL (Gaining Options: Girls Investigate Real Life) program was designed to help potentially talented at-risk girls. The program aimed to build mathematical confidence, skills, and conceptual understanding by integrating mathematics and social science research in a single-sex, technology-rich environment supported by university student mentors. The program targeted seventh-grade urban girls from public and private schools. Participants met over the course of ten Saturdays to learn research methods, computer skills, mathematics, and descriptive statistics. Quantitative data from the girls indicate that participants demonstrated greater confidence in their mathematics ability and increased mathematics achievement after the program. Qualitative data confirmed these findings and supported the contention that multiple factors play a role in fostering girls' interest in studying mathematics and science.