In this study, the primary goal was to enhance the knowledge and awareness of 4th-grade primary school students regarding global pandemic diseases and methods of safeguarding against worldwide epidemic diseases which are socio-scientific issues. To achieve this goal, two activity modules tailored for 4th-grade students were created. These encompassed various activities, including experiments, worksheets on scientific process skills, science-themed interactive reading, and poster development. The research was conducted at a public school during the 2022-2023 academic year, utilising a qualitative research methodology. Data were collected through pre- and post-implementation interviews. The findings of the study indicated that students were able to articulate accurate scientific information about global pandemics and protective measures. They also demonstrated an ability to implement preventive measures in their daily lives and share information about global pandemics with their families and friends. Furthermore, it was observed that students developed a more positive perception of scientists.