The purpose of this feasibility study was to examine the potential impact of reading digital interactive e-books, Word Knowledge e-books (WKe-Books), on essential skills that support reading comprehension with third-fifth grade students. Students (N= 425) read two WKe-Books, that taught word learning and comprehension monitoring strategies in the service of learning difficult vocabulary and targeted science concepts about hurricanes. We investigated whether specific comprehension strategies -- 1) word learning and strategies that supported general reading comprehension, 2) summarization, and 3) question generation, show promise of effectiveness in building vocabulary knowledge and comprehension skills in the WKe-Books. Students were assigned to read one of three versions of each of the two WKe-Books, each version implemented one strategy. The books employed a choose-your-adventure format with embedded comprehension questions that provided students with immediate feedback on their responses. Paired samples t-tests were run to examine pre-to-post differences in learning the targeted vocabulary and science concepts taught in both WKe-Books. For both WKe-Books, students demonstrated significant gains in word learning and on the targeted hurricane concepts. Additionally, Hierarchical Linear Modeling (HLM) revealed that no one strategy was more associated with larger gains than the other. Performance on the embedded questions in the books was also associated with greater posttest outcomes for both WKe-Books. These findings suggest that the affordances offered by technology, which are unavailable in paper-based books, can effectively support students' development of reading-related skills, including strategy use. Further, this work discusses important considerations for implementation and future development of e-books that can enhance student engagement and improve reading comprehension. [This paper was published at "arXiv" 2024.]