This research aims to evaluate the predicting role of executive functions, specially inhibition and flexibility, in reading comprehension. Participants were evaluated with inhibition and flexibility measures in first- grade, and later in third- grade their reading comprehension, oral and silent reading fluency, as well as their decoding skills were measured. Results show that first grade inhibition and flexibility are direct predictors of third- grade reading comprehension. When the indirect effect of inhibition and flexibility on reading comprehension was tested through measures of reading fluency and decoding, it was found that neither ORF nor decoding mediates the relationship between the variables. However, it was found that SRF is a variable that mediates the relationship between flexibility and reading comprehension. Results are discussed in the context of the relevance of early measures of inhibition and flexibility to explain reading comprehension and the role of SRF in this relationship.