The Ready for School, Ready for Life initiative in Guilford County, North Carolina, aims to support interconnected programs and services for young children and their families with the goal of having children enter kindergarten ready for learning. The initiative aims to strengthen connections among existing programs in Guilford County and provide sustainable and comprehensive support for families and young children through universal screening for strengths and needs, followed with connections to targeted services. Launched in 2018, the initiative has eight components focusing on families and children prenatally through age 3, clustered in three areas: building a system of care, expanding and improving services, and changing systems and building public will. This report provides an overview of the early phases of the initiative, and of MDRC's evaluation of it--the Guilford Readiness of Children for School (ROCS) study--which includes an implementation substudy and an outcomes-monitoring substudy. It also summarizes MDRC's analyses regarding the feasibility of evaluating the impacts of the initiative and conducting cost-benefit analyses of it.