Purpose: The purpose of this study was to determine prekindergarten predictors of listening comprehension in second grade. Methods: Within a large, 5-year longitudinal study, children progressing from prekindergarten to second grade were administered a comprehensive set of prekindergarten measures of foundational language skills (vocabulary and grammar), higher-level language skills (inferencing, comprehension monitoring, and text structure knowledge), listening comprehension, working memory, and nonverbal processing, as well as second grade measures of listening comprehension. Results: A prekindergarten measure of listening comprehension--the "Test of Narrative Language"--and a prekindergarten measure of foundational language skills and working memory--the "Clinical Evaluation of Language Fundamentals-4" Recalling Sentences--were significant predictors of second grade listening comprehension. Conclusions: Our findings show that a quick, reliable measure of sentence imitation and/or listening comprehension, administered in prekindergarten, provides insight into a child's second grade listening comprehension. Knowing who is at risk for comprehension failure will allow educators to make informed, evidence-based decisions on the need for further in-depth assessment and language-intensive instruction to stave off future reading disabilities. [This article was prepared by a Task Force of the Language and Reading Research Consortium (LARRC) consisting of Tiffany Hogan (Convener), Crystle Alonzo, Gloria Yeomans-Maldonado, Kimberly Murphy, Beau Bevens, Kate Cain, and Hugh Catts.]