Waterford Early Reading Program[TM] is a software-based curriculum for students in Kindergarten through second grade. The curriculum is designed to promote reading, writing, and typing, incorporating literacy skills such as letter mastery, language stories, spelling, basic writing skills, reading and listening development, and comprehension strategies. It can be used as a supplement to the regular reading curriculum. Program materials include classroom lessons and take-home materials in addition to the Waterford software. The What Works Clearinghouse (WWC) reviewed 36 studies on Waterford Early Reading Program[TM]. One study met WWC evidence standards with reservations; the remaining studies did not meet WWC evidence screens. Based on the one study, the WWC found potentially positive effects on alphabetics and no discernible effects on comprehension. The evidence presented in this report may change as new research emerges. Five appendices are included: (1) Study characteristics; (2) Outcome measures: (3) Summary of study findings; (4) Ratings by domain; and (5) Extent of evidence by domain. (Contains 17 footnotes.) [For "Waterford Early Reading Level One [TM]," WWC review of emergent literacy curriculum, see ED497611.]