This occasional paper presents national demographic subgroup data for the 1975-2022 Monitoring the Future (MTF) national survey results on 8th, 10th, and 12th graders' use of drugs, alcohol, and tobacco. The study covers all major classes of illicit and licit psychoactive drugs for an array of population subgroups. The 2020 subgroup data presented in this report accompany the "Monitoring the Future National Survey Results on Drug Use: 1975-2022: Overview, Key Findings on Adolescent Drug Use" (ED627365) and the "Monitoring the Future National Survey Results on Drug Use, 1975-2022: Secondary School Students" (ED627366). The trends shown in both tabular and graphic forms in this report cover demographic subgroups based on: (1) Gender; (2) College plans; (3) Region of the country; (4) Population density; (5) Education level of the parents (a proxy for socioeconomic level); and (6) Racial/ethnic identification.