A survey of 6th-12th grade students was conducted to measure their science-related attitudes and interests. Significant gender differences were found among these students. Females reported more anxiety about science as well as less motivation in and enjoyment of science than males. In spite of their unfavorable attitudes toward science, a large percentage of females expected to pursue a college major and subsequent career in the health sciences. We discuss reasons for the disconnect between female students' attitudes and their choice of college major and career. (Contains 9 tables and 1 figure.)