Background: Bullying has been associated with several adverse health outcomes, including substance use. However, little is known about the association between bullying and e-cigarette use. This study examined the association between bully victimization and the frequency of e-cigarette use. Methods: Data from the 2016-2017 Canadian Student Tobacco, Alcohol and Drugs Survey were used (N = 49,543). The target population consists of Canadian students enrolled in grades 7-12. Multivariable logistic regression models were used to examine the association between bullying victimization status and e-cigarette use. Results: Among the students included in the study, 14.1% were bullied less than once a week. Bullying victimization was statistically significantly associated with higher odds of any e-cigarette use in the last 30 days. Likewise, those bullied daily or almost daily were more likely to use e-cigarettes more frequently compared to students not bullied. We found a statistically significant difference in analysis stratified by sex, with female bullying victims having higher odds of all measures of e-cigarette use. Conclusions: Bullying victims were significantly more likely to use an e-cigarette, and findings appeared to vary by sex. Female bullying victims had a higher likelihood of e-cigarette use.