The study aimed at investigating the effect of using the "SQP2RS via WTL" strategy through science context to 10th graders' reading comprehension in English in Bethlehem district in Palestine. The study has been applied on a purposeful sample of 10th grade students at public schools in Bethlehem district in the academic year 2015/2016. The sample included (139) students (61 males and 78 females) at AL-Awda Basic School for Girls, Bethlehem Secondary Boys' School. Students were assigned to experimental and control groups, the experimental group was taught by using the "SQP2RS via WTL" strategy, while the control group was taught by the traditional method. The researchers have prepared a reading comprehension achievement test. Content validity and reliability were established for the test. The experiment has lasted three months, a pre-test and post-test were performed using the reading comprehension achievement test to measure the effect of using the "SQP2RS via WTL" strategy. The means and standard deviation, (3-way ANCOVA) test, were used in the study. The findings of the study showed that there were statistically significant differences in the mean scores of 10th graders' reading comprehension in the English language due to the teaching method in favor of the experimental group, the level of pre-achievement in favor of the high achievement group, the interaction between group and gender in favor of the female in the experimental group, the interaction between group and level of pre-achievement in favor of the high achievement in the experimental group, the interaction between gender and level of pre-achievement in favor of the male in the high achievement group and the interaction between group, gender and level of pre-achievement in favor of the high achievement male students in the experimental group. And there were no statistically significant differences in the mean scores of 10th graders' reading comprehension in the English language due to gender. In the light of the results of the study, training programs should be offered to train teachers on using the "SQP2RS via WTL" strategy, students should be provided with opportunities to practice the strategy, and more studies should be conducted on different variables and different populations.