The present research was conducted to identify the effectiveness of a training program based on practice of careers in vocational interests development, to answer questions about the study and test its hypothesis the training program had been prepared and the adoption of a measure of vocational interests, as validity and reliability of each of them were verified. The study sample consisted of (60) female students from the tenth grade in a school in Ma'an, where we were taking the two sections at the school and was selected one at random to be the experimental group and studied using a training program based on the practice of the professions and the other as a control and studied using a theoretical method about professions . Both groups were subjected to a vocational before and after interests scale. The study results indicated the presence of a statistically significant difference for the significance level a = 0.05 in the vocational interests between the experimental group and the control group and the experimental group in various professions (Medical, Engineering, Social, Applied Sciences, Business, Educational, Office Arts, Industrial, Military), the results showed that the practice of occupations develop real vocational interests for students, and the study set a recommendations from the results.