The world outside schools is changing rapidly with the advances of technology and economic requirements for a 21st-century global citizenry. Today, technology has moved into one's everyday life and is becoming a pervasive part of how one works, learns, and plays. Similarly, networked communications and computer technology have transformed the modern workplace dramatically, touching nearly every career and job category from entry level to seasoned professional--making skills once confined to a small group of technology enthusiasts into basic requirements for the mainstream and bringing the global community closer to one's doorstep. In New York City, the leadership in cooperation with philanthropic and corporate sponsors promoted early on the broad and passionate implementation of 21st Century education and introduced a small-scale innovative technology infrastructure and tools, and administrative and instructional policies and practices, which have disrupted the system and are now being scaled up throughout the system. Cisco asked researchers at Education Development Center, Inc. (EDC), a not-for-profit education organization, to identify the lessons learned from the implementation of the iSchool in New York City and to translate these lessons into actionable thematic areas for education leaders and decision-makers involved in implementing and scaling up education reform efforts. Drawing from the successes and challenges experienced at the iSchool, the research team aims to inform the development of a replicable model for transforming schools into 21st-century education systems. Codifying Innovations: Interview Protocol New York City iSchool is appended. (Contains 1 figure and 5 footnotes.)