Even after acting on the best available information to make a grantmaking decision, a grantmaker should seek to learn from grantees, remain adaptable to new ideas and open to unexpected learning, and willing to admit when grants do not turn out as expected. To this end, Grantmakers for Education's Principles for Effective Education Grantmaking identifies "innovation" and "constant learning" as a core principle for achieving results in education philanthropy. This case study indicates the practices and challenges inherent in using new information and knowledge to improve grantmaking. It also touches on another Principle for Effective Education Grantmaking, "effective grantees." The case features the Noyce Foundation and its flagship initiative, Every Child a Reader and Writer, which aims both to improve literacy achievement for students in grades K-5 and to create a replicable model for improving teaching and learning in school systems. As part of its significant commitment to the initiative, the foundation worked alongside its grantees. It carefully watched the initiative's progress, assessed what was needed to solve unexpected problems, and provided extra resources and expert assistance when needed. (Contains 3 tables, 6 exhibits and 5 footnotes.) [For "Learning by Doing: The Noyce Foundation's Every Child a Reader and Writer Initiative. Principles for Effective Education Grantmaking. Case in Brief Number 4," see ED537182.]