In this report, the authors introduce one of the unexplored effects of the opioid crisis, the link between the opioid epidemic and the education outcomes of children in hard-hit areas. Children, of course, are not immune to the effects of what may happen in their homes and communities, and there is ample evidence that negative home or community factors can be associated with lost learning opportunities. One example is that children exposed to higher levels of neighborhood violence have worse education outcomes than children who are less exposed. In a similar vein, childhood exposure to the ravages of the opioid epidemic may result in worse education outcomes. Education can be a pathway to economic and social mobility, especially for children from disadvantaged backgrounds. The collateral consequences associated with the opioid epidemic--family members who suffer from substance-use disorder, parents lost to opioid overdose, diverted community resources, and the fraying of neighborhood social connections--have the potential to negatively impact the educational outcomes of children. This may especially be the case for children who grow up in communities hardest hit by the epidemic, such as the Appalachian belt, impoverished rural communities, and the industrial Midwest, potentially exacerbating already existing educational achievement gaps and thus future economic opportunity.