The perspective of learning science as a way of thinking and inquiry can be realized if teachers can develop higher order thinking skills (HOTS)-oriented science worksheets. Therefore, it is very important to train the creativity of Pre-service Elementary School Teachers (PETs) in developing HOTS-oriented science worksheets in the education of prospective elementary school teachers. This study aims to describe the profile of PETs' creative thinking in developing HOTS-oriented science worksheets. Research involving PETs in one of the universities in Central Java. Data collection was carried out through a creative thinking assessment rubric on worksheet products on 38 PETs. Content analysis with an interactive model is applied in research. The results showed that the aspects of fluency, flexibility, and elaboration were obtained in the sufficient category. While the aspect of originality obtained unfavorable results. The results of the study concluded that creative thinking skills in developing HOTS-oriented science worksheets were still not good. Research recommends that lecturers immediately make efforts to select effective learning methods and tools to enhance PETs' creativity in developing HOTS-oriented science worksheets.