The process of perceiving music involves the transference of environmental physics in the air to anatomical and physiological interpretations of resonance in the body and psychological perceptions in the brain. These processes and musical interpretations are the basis of physical and cognitive science, neurophysiology, psychoacoustics, and cultural psychology. The intersection of interdisciplinary and transdisciplinary curricular offerings forms the basis of STEM (Science, Technology, Engineering, and Mathematics). In this study, the researcher explores the synergy of music in STEM for formulating and affording authentic STEAM programmatic offerings for learners. The blending of the art of music within STEM provides opportunities for teachers and students to address and connect content through creative, innovative approaches for deeper, meaningful learning. Threading the art of music within STEM affords discovery-learning opportunities that facilitate both critical thinking and social, emotional learning skills development in students. This study provides perspective in terms of developing curricular offerings for students that blend physical and cognitive science with the art of sound. The researcher provides authentic curricular exemplars regarding the synergy of music in STEM and concludes by offering recommendations for designing and implementing expressive curricular programmatic offerings for students from early childhood settings through higher education.