With a non-clinical sample of pre-schoolers, we used partial least squares regression to assess the extent to which children's seven sensory regulatory factors (X) account for variations in the three temperament factors (Y) and Y explains variations in X. The results suggested predicting temperament factors from sensory processing factors receive better outcomes. Finally, multiple regression analyses using the sensory processing measures to predict each of the three temperamental variables showed that (1) significant predictors of negative affectivity included difficulties in tactile sensitivity, taste/smell sensitivity, and low energy; (2) surgency was predicted by underresponsive/seeks sensation, auditory filtering, tactile sensitivity, and movement sensitivity; and (3) effortful control was predicted by low energy and auditory filtering. The hypothesis supported children's sensory processing preferences form the basis for the manifestation of temperament. Parents and educators need to notice environmental stimuli can cause challenges for children with sensory processing difficulties and manifesti difficult temperament.