The purpose of this study was to ascertain vocational interests and self-estimated work-relevant abilities of young adults with disabilities. Results showed that young adults with both low incidence and high incidence disabilities have a wide range of interests and self-estimated work-relevant abilities that are comparable to those in the general population. However, in this sample, less than 50% were employed in jobs that matched their Holland Theme interest/ability profiles. Suggestions for both employers and counselors to assist young adults with disabilities to work in employment that is satisfying and congruent with their vocational personalities are offered. (Contains 2 tables.)