The purpose of this article is to provide continuing higher education leaders with a comprehensive overview of the major considerations for doing business in the global market. Included is an analysis of the driving forces in global higher education and current trends in cross-border programs and a brief review of activities that may be part of a universitySSRqs internationalism strategy. This is followed by a discussion of selected challenges for universities exploring global opportunities. The article concludes with perspectives on the role of continuing education units in supporting a universitySSRqs internationalism strategy and offers a summary of effective strategies for managing global partnerships. The author argues that continuing education leaders must position their units strategically at the internationalism table and conduct an inventory of the unitSSRqs proven attributes that align with global program delivery. Most important, they must recognize that the SSLqrules of the gameSSRq for doing business globally require openness to different language, cultural, social, legal, and educational norms.