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Martin, Kiley; Musaus, Madeline; Navabpour, Shaghayegh; Gustin, Aspen; Ray, W. Keith; Helm, Richard F.; Jarome, Timothy J. – Learning & Memory, 2021
Strong evidence supports a role for protein degradation in fear memory formation. However, these data have been largely done in only male animals. Here, we found that following contextual fear conditioning, females, but not males, had increased levels of proteasome activity and K48 polyubiquitin protein targeting in the dorsal hippocampus, the…
Descriptors: Fear, Memory, Gender Differences, Animals
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Sneddon, Elizabeth A.; Riddle, Collin A.; Schuh, Kristen M.; Quinn, Jennifer J.; Radke, Anna K. – Learning & Memory, 2021
Early life stress (ELS) experiences can cause changes in cognitive and affective functioning. This study examined the persistent effects of a single traumatic event in infancy on several adult behavioral outcomes in male and female C57BL/6J mice. Mice received 15 footshocks in infancy and were tested for stress-enhanced fear learning, extinction…
Descriptors: Fear, Trauma, Animals, Stress Variables