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The Consequences of Neglected Confounding and Interactions in Mixed-Effects Meta-Regression: An Illustrative Example
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Knop, Eric S.; Pauly, Markus; Friede, Tim; Welz, Thilo – Research Synthesis Methods, 2023
Analysts seldom include interaction terms in their meta-regression model, which can introduce bias if an interaction is present. We illustrate this by reanalysing a meta-regression study in acute heart failure. Based on a total of 285 studies, the 1-year mortality rate related to acute heart failure is considered and the connection to the…
Descriptors: Regression (Statistics), Meta Analysis, Death, Heart Disorders