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Hamza, Tasnim; Chalkou, Konstantina; Pellegrini, Fabio; Kuhle, Jens; Benkert, Pascal; Lorscheider, Johannes; Zecca, Chiara; Iglesias-Urrutia, Cynthia P.; Manca, Andrea; Furukawa, Toshi A.; Cipriani, Andrea; Salanti, Georgia – Research Synthesis Methods, 2023
In network meta-analysis (NMA), we synthesize all relevant evidence about health outcomes with competing treatments. The evidence may come from randomized clinical trials (RCT) or non-randomized studies (NRS) as individual participant data (IPD) or as aggregate data (AD). We present a suite of Bayesian NMA and network meta-regression (NMR) models…
Descriptors: Meta Analysis, Regression (Statistics), Outcomes of Treatment, Research Methodology
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Papakonstantinou, Theodoros; Nikolakopoulou, Adriani; Egger, Matthias; Salanti, Georgia – Research Synthesis Methods, 2021
Meta-analysis results are usually presented in forest plots, which show the individual study results and the summary effect along with their confidence intervals. In this paper, we propose a system of linear springs as a mechanical analogue of meta-analysis that enables visualization and enhances intuition. The length of a spring corresponds to a…
Descriptors: Meta Analysis, Research Methodology, Visualization, Intuition
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Nikolakopoulou, Adriani; Mavridis, Dimitris; Chiocchia, Virginia; Papakonstantinou, Theodoros; Furukawa, Toshi A.; Salanti, Georgia – Research Synthesis Methods, 2021
Background: Network meta-analysis (NMA) produces complex outputs as many comparisons between interventions are of interest. The estimated relative treatment effects are usually displayed in a forest plot or in a league table and several ranking metrics are calculated and presented. Methods: In this article, we estimate relative treatment effects…
Descriptors: Networks, Meta Analysis, Intervention, Evaluation Methods
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Luo, Yan; Chaimani, Anna; Furukawa, Toshi A.; Kataoka, Yuki; Ogawa, Yusuke; Cipriani, Andrea; Salanti, Georgia – Research Synthesis Methods, 2021
It is often challenging to present the available evidence in a timely and comprehensible manner. We aimed to visualize the evolution of evidence about antidepressants for depression by conducting cumulative network meta-analyses (NMAs) and to examine whether it could have helped the selection of optimal drugs. We built a Shiny web application that…
Descriptors: Networks, Network Analysis, Meta Analysis, Drug Therapy
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Seo, Michael; Furukawa, Toshi A.; Veroniki, Areti Angeliki; Pillinger, Toby; Tomlinson, Anneka; Salanti, Georgia; Cipriani, Andrea; Efthimiou, Orestis – Research Synthesis Methods, 2021
Network meta-analysis (NMA) can be used to compare multiple competing treatments for the same disease. In practice, usually a range of outcomes is of interest. As the number of outcomes increases, summarizing results from multiple NMAs becomes a nontrivial task, especially for larger networks. Moreover, NMAs provide results in terms of relative…
Descriptors: Networks, Network Analysis, Meta Analysis, Visualization