A non-inferiority design accepts the possibility of some efficacy loss, as part of a "successful", statistically significant result. That loss may be excessive when the non-inferiority threshold is lenient. However, even stringent significance thresholds and safety monitoring may fail to adequately protect study participants when the…

Objective: Biological and psychological factors contribute to coronary artery disease (CAD). The purpose of this study was to investigate the relationship between spiritual well-being and CAD severity and determine the mediating effects of anger rumination and worry on this relationship. Design: Descriptive, cross-sectional survey. Setting: Afshar…

Context: High-fidelity simulation can provide an ideal adjunct to clinical or real-world experience by providing a realistic and safe learning environment for the practice of low-incident encounters. Objective: Given that levels of perceived self-efficacy are malleable and high-fidelity simulation can provide many positive outcomes, the purpose of…

Background: The modifications of fluid viscosity and/or volume are common strategies in dysphagia management, with increased viscosity or reduced volume intended to reduce aspiration. Little attention has been given to whether cough response to aspiration varies across different viscosities and volumes. Aims: This prospective observational study…

Every 40 seconds, someone in the United States has a heart attack (Heart Disease and Stroke Statistics 2017). Students may experience or be affected by several incidences of heart attacks throughout their life. As such, students should be aware of the risk factors and learn the underlying reasons for a heart attack. Most students believe they are…

Diabetes and heart disease are among the leading causes of death and disability in the United States, and these conditions are especially prevalent in the South. South Carolina's persistent racial and socioeconomic disparities in chronic disease outcomes are well-documented, yet little is known about how health care practices in medically…

The competency-based undergraduate medical curriculum in the preclinical years requires clinical topics to be taught using a linker clinical case for students to appreciate the clinical application of basic sciences. The objective of this study was to evaluate student and faculty satisfaction regarding the construct and delivery of an aligned and…

Objective: This study compared physical activity (PA), physical function and quality of life in elderly individuals with coronary artery disease (CAD) and their non-CAD peers participating in community-based, maintenance cardiac rehabilitation (CR). Design: Cross-sectional study. Setting: Community-based maintenance CR programme. Methods: A total…

Background: Cardiometabolic risk factors are related to the early onset of chronic health conditions. Purpose: To identify factors associated with perceptions about the severity of three interrelated cardiometabolic risks (i.e., high blood pressure, obesity, and cardiovascular disease) among U.S. college students. Methods: Data were analyzed from…

Background: Over half of all firefighter deaths are due to heart attacks. Physical activity (PA) is a protective factor against cardiovascular disease, but most firefighters do not meet recommended PA levels. Volunteer firefighters (VFFs), particularly in rural areas, may have unique reasons for not meeting recommendations. Purpose: To examine…

We aim to provide insight into the cause-specific mortality of older adults with intellectual disability (ID), with and without Down syndrome (DS), and compare this to the general population. Immediate and primary cause of death were collected through medical files of 1,050 older adults with ID, 5 years after the start of the Healthy Ageing and…

Objective: To examine rural-urban differences in college students' cardiovascular risk perceptions. Participants: College students in rural (n = 61) and urban (n = 57) Kentucky counties were recruited from November 2012 to May 2014. Methods: This was a secondary data analysis of a cross-sectional study examining rural-urban differences in…

We examined the association between physical activity (PA), body mass index (BMI) and novel measures of subclinical cardiovascular disease (CVD) in 15 children with autism spectrum disorder (ASD) (mean age 7 ± 2 years, 2 girls). PA was objectively assessed using accelerometry as time spent in moderate-vigorous physical activity (MVPA). Arterial…

Background: It is thought that people with Down syndrome die younger than the general population, but that survival rates are improving. Methods: Five databases were searched for keywords related to intellectual disabilities, Down syndrome and mortality. Strict inclusion criteria were applied. Information from 34 selected studies was tabulated,…

Medical education is moving towards more interactive teaching methods. During Year 1 at Manchester Medical School (MMS), students study the heart in preparation for the hospital-based years of study. Cardiovascular disease (CVD) is the main cause of mortality worldwide and thus, the content studied in Year 1 is essential for practising clinicians.…