Typical laboratory exercises for undergraduate organic chemistry students involve bulk phase reactions with work up of product. In this study, students performed accelerated versions of the Katritzky reaction of para-substituted anilines with pyrylium salts in three ways: (i) by dropcasting reagents onto a paper surface and allowing solvent to…

The goal of this laboratory exercise was for students to understand the concept of chirality and how enantiomeric excess (ee) is experimentally determined using the analysis of ibuprofen as an example. Students determined the enantiomeric excess of the analyte by three different instrumental methods: mass spectrometry, nuclear magnetic resonance…

In this laboratory, students perform a synthetic reaction in two ways: (i) by traditional bulk-phase reaction and (ii) in the course of reactive paper spray ionization. Mass spectrometry (MS) is used both as an analytical method and a means of accelerating organic syntheses. The main focus of this laboratory exercise is that the same ionization…