N-of-1 trials, a special case of Single Case Experimental Designs (SCEDs), are prominent in clinical medical research and specifically psychiatry due to the growing significance of precision/personalized medicine. It is imperative that these clinical trials be conducted, and their data analyzed, using the highest standards to guard against threats…

The practice of prospectively registering the details of intervention studies in a public database or registry is gaining momentum across disciplines as a strategy for increasing the transparency, credibility, and accessibility of study findings. In this article, we consider five registries that may be relevant for registration of intervention…

Immediacy is one of the necessary criteria to show strong evidence of treatment effect in single case experimental designs (SCEDs). With the exception of Natesan and Hedges (2017) no inferential statistical tool has been used to demonstrate or quantify it until now. We investigate and quantify immediacy by treating the change-points between the…

Implementation Science has recently gained considerable attention for the discipline of Communication Sciences and Disorders as a promising means for closing the research-practice gap by proactively facilitating the use of evidence-based protocols in practice. One of the pillars of Implementation Science is collaboration between researchers and…

Biased sampling occurs frequently in economics, epidemiology, and medical studies either by design or due to data collecting mechanism. Failing to take into account the sampling bias usually leads to incorrect inference. We propose a unified estimation procedure and a computationally fast resampling method to make statistical inference for…