Given the differences in trajectory for under-represented minorities in biomedical careers, we sought to explore how a virtual mentoring program, the National Research Mentoring Network (NRMN), and its platform (MyNRMN), may facilitate transitions in the science, technology, engineering, mathematics, and medicine (STEMM) pipeline. The purpose of this study was to describe how the size of an MyNRMN member's mentoring network and level of engagement correlate with academic and career transitions. We examined MyNRMN platform user data from March 2020 to May 2021 (n = 2993). Logistic regression estimated the odds of a career or academic transition related to NRMN mentoring network size and engagement, while adjusting for confounders. Among active MyNRMN users for the one-year period, 5.2% (n = 155) had a positive transition. In the adjusted logistic regression model, users with more engagement on the MyNRMN platform (201 + points) had significantly higher odds of a positive transition (aOR = 2.19, 95% CI 1.14, 4.22) compared to those with 1-50 NRMN Points. Network size was not statistically significant. This study shows an association between being active within a virtual mentoring network and positive educational and career transitions in the STEMM pipeline. Active engagement in a virtual mentoring network may have benefits for mentees who aspire to join the STEMM workforce.