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Infant Vocalizing and Phenotypic Outcomes in Autism: Evidence from the First 2 Years
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Plate, Samantha; Yankowitz, Lisa; Resorla, Leslie; Swanson, Meghan R.; Meera, Shoba Sreenath; Estes, Annette; Marrus, Natasha; Cola, Meredith; Petrulla, Victoria; Faggen, Aubrey; Pandey, Juhi; Paterson, Sarah; Pruett, John R., Jr.; Hazlett, Heather; Dager, Stephen; St. John, Tanya; Botteron, Kelly; Zwaigenbaum, Lonnie; Piven, Joseph; Schultz, Robert T.; Parish-Morris, Julia – Child Development, 2022
Infant vocalizations are early-emerging communicative markers shown to be atypical in autism spectrum disorder (ASD), but few longitudinal, prospective studies exist. In this study, 23,850 infant vocalizations from infants at low (LR)- and high (HR)-risk for ASD (HR-ASD = 23, female = 3; HR-Neg = 35, female = 13; LR = 32, female = 10; 80% White;…
Descriptors: Infants, Toddlers, Verbal Communication, Autism
Assessment of Autism Symptoms from 6 to 18 Months of Age Using the Autism Observation Scale for Infants in a Prospective High-Risk Cohort
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Zwaigenbaum, Lonnie; Bryson, Susan E.; Brian, Jessica; Smith, Isabel M.; Sacrey, Lori; Armstrong, Vickie; Roberts, Wendy; Szatmari, Peter; Garon, Nancy; Vaillancourt, Tracy; Roncadin, Caroline – Child Development, 2021
The objectives were to characterize behavioral signs of autism spectrum disorder (ASD) in younger siblings of diagnosed children (high-risk; HR) and examine classification features of the Autism Observation Scale for Infants (AOSI). Participants (501 HR and 180 low-risk [LR]) were assessed between 6 and 18 months using the AOSI and at age 3 for…
Descriptors: Autism, Pervasive Developmental Disorders, Symptoms (Individual Disorders), Infant Behavior
Brief Report: Evaluation of the Short Quantitative Checklist for Autism in Toddlers (Q-CHAT-10) as a Brief Screen for Autism Spectrum Disorder in a High-Risk Sibling Cohort
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Raza, Sarah; Zwaigenbaum, Lonnie; Sacrey, Lori-Ann R.; Bryson, Susan; Brian, Jessica; Smith, Isabel M.; Reid, Kyle; Roberts, Wendy; Szatmari, Peter; Vaillancourt, Tracy; Roncadin, Caroline; Garon, Nancy – Journal of Autism and Developmental Disorders, 2019
This study examined the potential of the short form of the Quantitative Checklist for Autism in Toddlers (Q-CHAT-10) to identify autism spectrum disorder (ASD) in a high-risk sibling cohort. High-risk (HR; siblings of children diagnosed with ASD) and low-risk (LR; no family history of ASD) toddlers were assessed prospectively at 18 and 24 months…
Descriptors: Autism, Pervasive Developmental Disorders, Toddlers, At Risk Persons
Profiles of Social and Coping Resources in Families of Children with Autism Spectrum Disorder: Relations to Parent and Child Outcomes
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Zaidman-Zait, Anat; Mirenda, Pat; Szatmari, Peter; Duku, Eric; Smith, Isabel M.; Vaillancourt, Tracy; Volden, Joanne; Waddell, Charlotte; Bennett, Teresa; Zwaigenbaum, Lonnie; Elsabaggh, Mayada; Georgiades, Stelios – Journal of Autism and Developmental Disorders, 2018
This study described empirically derived profiles of parents' personal and social coping resources in a sample of 207 families of children diagnosed with autism spectrum disorder. Latent Profile Analysis identified four family profiles based on socieoeconomic risk, coping strategy utilization, family functioning, available social supports, and…
Descriptors: Coping, Pervasive Developmental Disorders, Autism, Behavior Problems
Relationship between Early Social-Emotional Behavior and Autism Spectrum Disorder: A High-Risk Sibling Study
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Raza, Sarah; Sacrey, Lori-Ann R.; Zwaigenbaum, Lonnie; Bryson, Susan; Brian, Jessica; Smith, Isabel M.; Roberts, Wendy; Szatmari, Peter; Vaillancourt, Tracy; Roncadin, Caroline; Garon, Nancy – Journal of Autism and Developmental Disorders, 2020
Social-emotional behavior in autism spectrum disorder (ASD) was examined among high-risk (HR; siblings of children diagnosed with ASD) and low-risk (LR; no family history of ASD) toddlers. Caregivers completed the Infant-Toddler Social Emotional Assessment (ITSEA) at 18 months, and blind diagnostic assessment for ASD was conducted at 36 months.…
Descriptors: Autism, Pervasive Developmental Disorders, Genetics, Clinical Diagnosis
Gender Differences in Pragmatic Communication in School-Aged Children with Autism Spectrum Disorder (ASD)
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Conlon, Olivia; Volden, Joanne; Smith, Isabel M.; Duku, Eric; Zwaigenbaum, Lonnie; Waddell, Charlotte; Szatmari, Peter; Mirenda, Pat; Vaillancourt, Tracy; Bennett, Teresa; Georgiades, Stelios; Elsabbagh, Mayada; Ungar, Wendy. J. – Journal of Autism and Developmental Disorders, 2019
Possible gender differences in manifestations of autism spectrum disorder (ASD) were examined using data on production of narratives. The Expression, Reception and Recall of Narrative Instrument (ERRNI; Bishop, Expression, Reception and Recall of Narrative Instrument, Harcourt assessment, London, 2004) was administered to a sample of matched…
Descriptors: Gender Differences, Pragmatics, Autism, Pervasive Developmental Disorders
Stability and Change in the Cognitive and Adaptive Behaviour Scores of Preschoolers with Autism Spectrum Disorder
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Flanagan, Helen E.; Smith, Isabel M.; Vaillancourt, Tracy; Duku, Eric; Szatmari, Peter; Bryson, Susan; Fombonne, Eric; Mirenda, Pat; Roberts, Wendy; Volden, Joanne; Waddell, Charlotte; Zwaigenbaum, Lonnie; Bennett, Teresa; Elsabbagh, Mayada; Georgiades, Stelios – Journal of Autism and Developmental Disorders, 2015
We examined the stability of cognitive and adaptive behaviour standard scores in children with autism spectrum disorder (ASD) between diagnosis and school entry approximately age 6. IQ increased 18 points in 2-year-olds, 12 points in 3-year-olds, and 9 points in 4-year-olds (N = 281). Adaptive behaviour scores increased 4 points across age groups…
Descriptors: Autism, Pervasive Developmental Disorders, Preschool Children, Mental Retardation
Stability and Change in Autism Spectrum Disorder Diagnosis from Age 3 to Middle Childhood in a High-Risk Sibling Cohort
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Brian, Jessica; Bryson, Susan E.; Smith, Isabel M.; Roberts, Wendy; Roncadin, Caroline; Szatmari, Peter; Zwaigenbaum, Lonnie – Autism: The International Journal of Research and Practice, 2016
Considerable evidence on autism spectrum disorder emergence comes from longitudinal high-risk samples (i.e. younger siblings of children with autism spectrum disorder). Diagnostic stability to age 3 is very good when diagnosed as early as 18-24 months, but sensitivity is weaker, and relatively little is known beyond toddlerhood. We examined…
Descriptors: Autism, Pervasive Developmental Disorders, Clinical Diagnosis, Toddlers
The Autism Parent Screen for Infants: Predicting Risk of Autism Spectrum Disorder Based on Parent-Reported Behavior Observed at 6-24 Months of Age
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Sacrey, Lori-Ann R.; Bryson, Susan; Zwaigenbaum, Lonnie; Brian, Jessica; Smith, Isabel M.; Roberts, Wendy; Szatmari, Peter; Vaillancourt, Tracy; Roncadin, Caroline; Garon, Nancy – Autism: The International Journal of Research and Practice, 2018
This study examined whether a novel parent-report questionnaire, the Autism Parent Screen for Infants, could differentiate infants subsequently diagnosed with autism spectrum disorder from a high-risk cohort (siblings of children diagnosed with autism spectrum disorder (n = 66)) from high-risk and low-risk comparison infants (no family history of…
Descriptors: Autism, Infants, Pervasive Developmental Disorders, Parents
Potential Risk Factors for the Development of Self-Injurious Behavior among Infants at Risk for Autism Spectrum Disorder
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Dimian, Adele F.; Botteron, Kelly N.; Dager, Stephen R.; Elison, Jed T.; Estes, Annette M.; Pruett, John R., Jr.; Schultz, Robert T.; Zwaigenbaum, Lonnie; Piven, Joseph; Wolff, Jason J. – Journal of Autism and Developmental Disorders, 2017
Prevalence of self-injurious behavior (SIB) is as high as 50% among children with autism spectrum disorder (ASD). Identification of risk factors for the development of SIB is critical to early intervention and prevention. However, there is little empirical research utilizing a prospective design to identify early risk factors for SIB. The purpose…
Descriptors: Risk, Self Destructive Behavior, Autism, Pervasive Developmental Disorders
Investigating Phenotypic Heterogeneity in Children with Autism Spectrum Disorder: A Factor Mixture Modeling Approach
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Georgiades, Stelios; Szatmari, Peter; Boyle, Michael; Hanna, Steven; Duku, Eric; Zwaigenbaum, Lonnie; Bryson, Susan; Fombonne, Eric; Volden, Joanne; Mirenda, Pat; Smith, Isabel; Roberts, Wendy; Vaillancourt, Tracy; Waddell, Charlotte; Bennett, Teresa; Thompson, Ann – Journal of Child Psychology and Psychiatry, 2013
Background: Autism spectrum disorder (ASD) is characterized by notable phenotypic heterogeneity, which is often viewed as an obstacle to the study of its etiology, diagnosis, treatment, and prognosis. On the basis of empirical evidence, instead of three binary categories, the upcoming edition of the DSM 5 will use two dimensions--social…
Descriptors: Pervasive Developmental Disorders, Autism, Student Characteristics, Social Development
Phenotypic Overlap between Core Diagnostic Features and Emotional/Behavioral Problems in Preschool Children with Autism Spectrum Disorder
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Georgiades, Stelios; Szatmari, Peter; Duku, Eric; Zwaigenbaum, Lonnie; Bryson, Susan; Roberts, Wendy; Fombonne, Eric; Mirenda, Pat; Smith, Isabel; Vaillancourt, Tracy; Volden, Joanne; Waddell, Charlotte; Thompson, Ann – Journal of Autism and Developmental Disorders, 2011
This study examined the phenotypic overlap between core diagnostic features and emotional/behavioral problems in a sample of 335 preschool children with autism spectrum disorder (ASD). Results from principal component analysis (2 components; 49.70% variance explained) suggested substantial phenotypic overlap between core diagnostic features and…
Descriptors: Autism, Preschool Children, Pervasive Developmental Disorders, Behavior Problems
Differentiating Autism and Asperger Syndrome on the Basis of Language Delay or Impairment
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Bennett, Terry; Szatmari, Peter; Bryson, Susan; Volden, Joanne; Zwaigenbaum, Lonnie; Vaccarella, Liezanne; Duku, Eric; Boyle, Michael – Journal of Autism and Developmental Disorders, 2008
Asperger syndrome (AS) is differentiated from high-functioning autism (HFA) largely on a history of "language delay." This study examined "specific language impairment" as a predictor of outcome. Language skills of 19 children with AS and 45 with HFA were assessed at 4-6 years of age (Time 1) and 2 years later (Time 2). Children's symptoms and…
Descriptors: Delayed Speech, Autism, Asperger Syndrome, Language Impairments
Studying the Emergence of Autism Spectrum Disorders in High-Risk Infants: Methodological and Practical Issues
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Zwaigenbaum, Lonnie; Thurm, Audrey; Stone, Wendy; Baranek, Grace; Bryson, Susan; Iverson, Jana; Kau, Alice; Klin, Ami; Lord, Cathy; Landa, Rebecca; Rogers, Sally; Sigman, Marian – Journal of Autism and Developmental Disorders, 2007
Detecting early signs of autism is essential for timely diagnosis and initiation of effective interventions. Several research groups have initiated prospective studies of high-risk populations including infant siblings, to systematically collect data on early signs within a longitudinal design. Despite the potential advantages of prospective…
Descriptors: Infants, Siblings, Autism, At Risk Persons