Over the past decade the academic literature on disability outcomes and effectiveness has grown substantially (Andresen, Lollar, & Meyers, 2000; Devon, Lydon, Healy, & McCoy, 2016; Iemmi et al., 2015). Several important questions have not been adequately addressed, however. For example, what type of evidence is needed, and what are realistic expectations for disability outcomes and effectiveness research? A lack of rigorous and comparable data on disability and evidence on programmes that work can impede understanding and action. Understanding the numbers of people with disabilities and their circumstances can improve efforts to remove disabling barriers and provide services to allow people with disabilities to participate on an equal basis with others. For example, better measures of the environment and its impacts on the different aspects of disability need to be developed to facilitate the identification of cost-effective environmental interventions. Knowledge production takes place across several sectors (health, social welfare and education), focuses on various populations (different ages, ethnicities, or with different needs), and involves rather diverse methodical approaches (e.g., systematic reviews, primary studies of different designs, etc.). A mapping of the existing knowledge base is therefore required to provide a comprehensive overview of existing knowledge in this area and enable the purposeful and targeted commissioning of future research, tailored to the most eminent needs for knowledge and guidance. This ambition could be fulfilled by a proposed evidence and gap map (EGM). The proposed EGM will present studies of the effectiveness of these interventions across a range of outcome domains. Specifically, the objectives of the map are to: (1) develop a clear framework of types of interventions and outcomes related to effectiveness of interventions for people with disabilities in low- and middle-income countries (LMICs); (2) map available systematic reviews and primary studies on the effectiveness of disability interventions in low- and middle-income countries in this framework, with an overview provided in a summary report; and (3) provide database entries of included studies which summarise the intervention, context, study design and main findings.