Parts 1 and 2 explore the hypothesis that the application of mainstream economics has led to economies becoming uneconomic, which is as close as a social science can get to experimentally disproving its theories. One of the primary reasons for this failure is traced to the characteristics of the knowledge infrastructures of contemporary societies, which began to act as the most influential factor of production during the second half of the 20th century. A new economic strategy is developed based on the restructuring of these knowledge infrastructures by means of preventive approaches. These can help to turn growth into development, and wealth extraction into wealth creation. Without this restructuring, the current economic, social, and environmental crises will inevitably deepen and possibly threaten our civilization. (Contains 2 tables.) [For Part 1, see EJ825551. For Part 2, see EJ825552.]