Equipping youth with and without disabilities for the world of work has been the focus of ongoing legislative and policy initiatives. The authors examined the extent to which career development and vocational activities were available to and accessed by youth with severe disabilities or emotional and behavioral disorders attending 34 urban, suburban, and rural high schools. Although school-level representatives (e.g., administrators, guidance counselors, student services directors) identified an array of career development opportunities offered by their schools, participation by youth with disabilities in these experiences was reported to be fairly limited. Potential factors influencing the participation of youth included disability-related needs and limited professional development opportunities for educators. The authors present recommendations for improving research and practice aimed at better preparing youth with disabilities for their future careers. (Contains 1 table and 1 figure.)