A camera-based microswitch technology was recently used to successfully monitor small eyelid and mouth responses of two adults with profound multiple disabilities (Lancioni et al., Res Dev Disab 31:1509-1514, 2010a). This technology, in contrast with the traditional optic microswitches used for those responses, did not require support frames on the participants' face but only small color marks. The present study was aimed at extending the research evidence available on the aforementioned technology with the involvement of new participants and responses. The participants were three children with profound multiple disabilities. The responses selected for them consisted of mouth closing, eyebrow lifting, and repeated eyelid closures. The results showed that the new technology could be satisfactorily applied with all three children, across the three different responses. All children had large increases in responding during the intervention periods (i.e., when their responses were followed by preferred stimulation). The findings are discussed in relation to the possible impact of the new technology on programs for persons with multiple disabilities and minimal motor behavior.