Science, technology, engineering, and mathematics (STEM) education programs help to enhance the nation's global competitiveness. Many federal agencies have been involved in administering these programs. Concerns have been raised about the overall effectiveness and efficiency of STEM education programs. GAO examined (1) the number of federal agencies and programs that provided funding for STEM education programs in fiscal year 2010; (2) the extent to which STEM education programs have similar objectives, serve similar target groups, and provide similar types of services, and, if necessary, what opportunities exist to increase coordination; and (3) the extent to which STEM education programs measured effectiveness. To answer these questions, GAO reviewed relevant federal laws, regulations, and plans; surveyed federal STEM education programs; analyzed programs' STEM evaluations; and interviewed relevant federal officials. An electronic supplement--GAO-12-110SP--provides survey results. GAO recommends that as OSTP leads the government-wide STEM education strategic planning effort, it should work with agencies to better align their activities with a government-wide strategy, develop a plan for sustained coordination, identify programs for potential consolidation or elimination, and assist agencies in determining how to better evaluate their programs. OSTP provided technical comments that we incorporated as appropriate. OMB had no concerns with the report. Appended are: (1) Objectives, Scope, and Methodology; (2) List of STEM Education Programs with Fiscal Year 2010 Obligations; (3) Review of Evaluations; and (4) GAO Contact and Staff Acknowledgments. (Contains 5 tables, 8 figures and 44 footnotes.)